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A randomized clinical pilot study involving children with acute lymphoblastic leukemia (ALL) found that milk thistle was associated with a reduction in liver toxicity caused by chemotherapy

Improvement timing varies

Posible desarrollo de resistencia a la insulina con el uso prolongado

634 AAK1 inhibitor LX-9211: Junctional protein 2-associated kinase 1 (AAK1) is widely expressed in the brain and spinal cord and is a viable target for the treatment of neuropathic pain, and BMS-986176/LX-9211 is a novel class of bis(iso)aryl ethers that are highly selective, CNS-permeable, and potent AAK1 inhibitors

Personal experience, it seems, points to modest, context-dependent effects, rather than dramatic changes